Thermo Fisher Scientific Catenin alpha-1 Polyclonal Antibody
Catenin alpha-1 단백질을 검출하기 위한 Thermo Fisher Scientific의 폴리클로날 항체입니다. 인간, 마우스, 랫트, 제브라피쉬 등 다양한 종에 반응하며, WB, IHC, ICC 등 다양한 응용에 적합합니다. 항원 친화 크로마토그래피로 정제된 고품질 항체로 세포 접착 및 분화 연구에 활용됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:10,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 |
| Immunohistochemistry (Frozen) (IHC (F)) | Assay-dependent |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat, Zebrafish |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein encompassing a sequence within the center region of human alpha 1 Catenin |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.87 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 20% glycerol |
| Contains | 0.025% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2792441 |
Product Specific Information
- Keep as a concentrated solution.
- Predicted reactivity: Mouse (100%), Rat (100%), Zebrafish (91%), Xenopus laevis (93%), Rabbit (100%), Rhesus Monkey (100%), Bovine (100%).
- Positive Control: 293T, A431, H1299, HeLaS3, HepG2, NIH-3T3, JC, PC-12.
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Catenin alpha-1 associates with the cytoplasmic domain of various cadherins. The catenin–cadherin complex links to the actin filament network and plays a key role in cadherin-mediated cell adhesion. It can associate with both E- and N-cadherins. Although previously thought to stably link cadherins to actin, recent findings suggest CTNNA1 does not bind F-actin in the complex, indicating a distinct linkage mechanism. The homodimeric form may regulate actin filament assembly and inhibit branching by competing with the Arp2/3 complex for actin binding, thus playing a crucial role in cell differentiation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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