Thermo Fisher Scientific CD105 Monoclonal Antibody (MEM-226)
CD105(Endoglin)을 인식하는 MEM-226 단클론 항체로, 인간 및 랫드 시료에 반응합니다. Western blot, Flow cytometry, Immunoprecipitation 등 다양한 응용에 적합합니다. 비결합형 액상 형태로, Protein A로 정제되었으며 4°C에서 보관합니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | View 1 publication |
| Flow Cytometry (Flow) | 1–5 µg/mL | View 2 publications |
| Immunoprecipitation (IP) | Assay-dependent | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Published species | Rat |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | MEM-226 |
| Immunogen | Recombinant Vaccinia virus containing the human CD105 cDNA |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage buffer | PBS, pH 7.4 |
| Contains | 15 mM sodium azide |
| Storage conditions | 4°C, do not freeze |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1071115 |
Additional Formats
Product Specific Information
This antibody reacts with an extracellular epitope of CD105 (Endoglin), a 90 kDa type I homodimerizing membrane glycoprotein expressed on vascular endothelial cells (small and large vessels), activated monocytes and tissue macrophages, stromal cells of certain tissues including bone marrow, pre-B lymphocytes in fetal marrow, and erythroid precursors in fetal and adult bone marrow. It is also present on syncytiotrophoblasts in the placenta throughout pregnancy.
This antibody has been successfully used in Mass Cytometry (CyTOF).
Target Information
CD105 (Endoglin) is a type I transmembrane protein highly expressed on human vascular endothelial cells. It exists as an O- and N-glycosylated homodimer. Upregulation of endoglin expression has been demonstrated in tumor vasculature and proliferating cells, suggesting it is a proliferation-associated endothelial marker. CD105 binds to TGF-β1 and TGF-β3 with high affinity but not to TGF-β2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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