Thermo Fisher Scientific NK1.1 Monoclonal Antibody (PK136)

Applications

Tested Dilution

Publications

Immunohistochemistry (IHC)

-

View 8 publications 8 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:100

View 1 publication 1 publication

Flow Cytometry (Flow)

0.5 µg/1 million cells

View 6 publications 6 publications

ChIP assay (ChIP)

-

View 1 publication 1 publication

Product Specifications

Species Reactivity

Mouse

Published species

Human, Mouse

Host/Isotype

Mouse / IgG2a

Class

Monoclonal

Type

Antibody

Clone

PK136

Immunogen

NK-1+ cells from mouse spleen and bone marrow if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:NK1.1,uniProtId:P27814-1,ncbiNodeId:10090,antigenRange:1-223,antigenLength:223,antigenImageFileName:MA1-70100_NK1.1_P27814-1_House_mouse.svg,antigenImageFileNamePDP:MA1-70100_NK1.1_P27814-1_House_mouse_PDP.jpeg,sortOrder:1},{targetFamily:NK1.1,uniProtId:P27812-1,ncbiNodeId:10090,antigenRange:1-223,antigenLength:223,antigenImageFileName:MA1-70100_NK1.1_P27812-1_House_mouse.svg,antigenImageFileNamePDP:MA1-70100_NK1.1_P27812-1_House_mouse_PDP.jpeg,sortOrder:2}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

View additional formats

• Biotin
• FITC
• PE
• Request custom conjugation

Form

Liquid

Concentration

1 mg/mL

Purification

Protein G

Storage buffer

PBS

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2296673

Product Specific Information

Clone PK136 is specific for mouse NK1.1, also known as NKR-PIC and Ly-55. Mouse NK1.1 is expressed on NK cells and NKT cells on the following strains: C57BL, FVB/N and NZB. There are published reports that PK136 also binds to NKR-PIB on SJL/K NK cells.

In addition to Flow and IHC, this clone has also been reported to work for in-vitro and in-vivo depletion assays.

Target Information

NK1.1 (Killer cell lectin-like receptor subfamily B, member 1, KLRB1, NKR-P1A, CD161, cluster of differentiation 161), refers to Natural Killer (NK) cells, lymphocytes that mediate cytotoxicity and secrete cytokines after immune stimulation. Several genes of the C-type lectin superfamily, including the rodent NKRP1 family of glycoproteins, are expressed by NK cells and may be involved in the regulation of NK cell function. The KLRB1 protein contains an extracellular domain with several motifs characteristic of C-type lectins, a transmembrane domain, and a cytoplasmic domain. The KLRB1 protein, NKR-P1A or CD161, is classified as a type II membrane protein because it has an external C terminus. NKR-P1A, the receptor encoded by the KLRB1 gene, recognizes Lectin Like Transcript-1 (LLT1) as a functional ligand.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.