Thermo Fisher Scientific TGIF1 Monoclonal Antibody (OTI1B12), TrueMAB

Applications and Tested Dilutions

Product Specifications

Product Specific Information

For reconstitution, add 100 µL of distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

TGIF is a member of the three-amino acid loop extension (TALE) superclass of atypical homeodomains. TALE homeobox proteins are highly conserved transcription regulators.
This homeodomain binds to a retinoid X receptor responsive element from the cellular retinol-binding protein II promoter.
TGIF inhibits 9-cis-retinoic acid-dependent RXRα transcription activation and acts as a transcriptional co-repressor of SMAD2.
It may play a role in transmitting nuclear signals during development and adulthood.
Mutations in TGIF1 are associated with holoprosencephaly type 4, a structural anomaly of the brain.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.