Thermo Fisher Scientific TGIF1 Monoclonal Antibody (OTI1G5), TrueMAB
TGIF1 단백질을 인식하는 Mouse IgG1 단클론 항체로, Western blot 등에 사용 가능. E.coli에서 발현된 full-length human TGIF1 단백질로 면역화됨. 동결건조 형태로 제공되며, PBS(pH 7.3) 및 8% 트레할로스를 포함. 연구용으로만 사용 가능.
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Applications
- Western Blot (WB): Tested dilution 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1G5 |
| Immunogen | Full length human recombinant protein of human TGIF1 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to reach a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
TGIF is a member of the three-amino acid loop extension (TALE) superclass of atypical homeodomains. TALE homeobox proteins are highly conserved transcription regulators.
This homeodomain binds to a retinoid X receptor responsive element from the cellular retinol-binding protein II promoter. TGIF inhibits 9-cis-retinoic acid-dependent RXRα transcription activation and acts as a transcriptional co-repressor of SMAD2.
It may play a role in nuclear signal transmission during development and adulthood. Mutations in TGIF1 are linked to holoprosencephaly type 4, a structural brain anomaly.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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