Thermo Fisher Scientific Phospho-Aurora A/B/C (Thr288, Thr232, Thr198) Recombinant Rabbit Monoclonal Antibody (AuroraABC-CC12), APC
Aurora A/B/C 인산화 단백질(Thr288/Thr232/Thr198)을 인식하는 재조합 토끼 단클론 항체로, APC 형광체가 결합되어 있습니다. Flow Cytometry에 적합하며, 높은 특이성과 신뢰성을 제공합니다. 연구용으로만 사용 가능합니다.
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Applications
Flow Cytometry (Flow)
- Tested Dilution: 5 µL / 1×10⁶ cells
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | AuroraABC-CC12 |
| Immunogen | A synthetic phospho-peptide corresponding to residues surrounding human Aurora A (Thr288) / Aurora B (Thr232) / Aurora C (Thr198) |
| Conjugate | APC |
| Excitation / Emission Max | 651 / 660 nm |
| Form | Liquid |
| Purification | Protein A/G |
| Storage Buffer | PBS with 0.20% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2897089 |
Additional Formats
- Unconjugated (MA5-37152)
- FITC (MA5-37154)
- PE (MA5-37153)
- Custom conjugation available upon request
Target Information
Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a key regulator of mitosis.
The CPC ensures correct chromosome alignment and segregation and is essential for chromatin-induced microtubule stabilization and spindle assembly.
It regulates cytokinesis onset, spindle formation, and cleavage furrow formation.
AURKB phosphorylates CPC subunits (BIRC5, CDCA8, INCENP) and several substrates (CENPA, DES, VIM, histone H3, etc.), controlling chromosome segregation and cytokinetic processes.
It also modulates p53 transcriptional activity and participates in checkpoint control during cell division.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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