Thermo Fisher Scientific Phospho-Aurora A/B/C (Thr288, Thr232, Thr198) Recombinant Rabbit Monoclonal Antibody (AuroraABC-CC12), FITC
Aurora A/B/C 인산화 단백질(Thr288, Thr232, Thr198)을 인식하는 FITC 결합 재조합 토끼 단클론 항체. 세포주기 조절 연구에 적합하며, Flow Cytometry에 최적화됨. HEK293 발현 시스템에서 생산, Protein A/G 정제, 4°C 암소 보관.
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Applications
- Flow Cytometry (Flow): 5 µL / 1×10⁶ cells
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | AuroraABC-CC12 |
| Immunogen | A synthetic phospho-peptide corresponding to residues surrounding human Aurora A (Thr288) / Aurora B (Thr232) / Aurora C (Thr198). |
| Conjugate | FITC |
| Excitation / Emission Max | 498 / 517 nm |
| Form | Liquid |
| Purification | Protein A/G |
| Storage Buffer | PBS with 0.20% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2897088 |
Additional Formats
Target Information
Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a key regulator of mitosis. The CPC ensures correct chromosome alignment and segregation, chromatin-induced microtubule stabilization, and spindle assembly. It is essential for cytokinesis, central spindle assembly, and cleavage furrow formation. The complex phosphorylates multiple substrates including BIRC5, CDCA8, INCENP, CENPA, and histone H3, contributing to mitotic progression and checkpoint regulation. AURKB also regulates p53 transcriptional activity and is vital for kinetochore localization of BUB1 and SGOL1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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