Thermo Fisher Scientific Phospho-Aurora A/B/C (Thr288, Thr232, Thr198) Recombinant Rabbit Monoclonal Antibody (AuroraABC-CC12)
Aurora A/B/C 단백질의 인산화 형태(Thr288, Thr232, Thr198)를 특이적으로 인식하는 재조합 토끼 단일클론 항체. Flow Cytometry에 적합하며, 고순도 Protein A/G 정제. 인간 시료 반응성, 다양한 형광 접합 옵션 제공. 연구용 전용.
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Applications
- Flow Cytometry (Flow)
Tested Dilution
- 1–1,000 ng/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | AuroraABC-CC12 |
| Immunogen | A synthetic phospho-peptide corresponding to residues surrounding human Aurora A (Thr288), Aurora B (Thr232), and Aurora C (Thr198). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS with 50% glycerol, 0.10% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2897086 |
Additional Formats
Target Information
Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a key regulator of mitosis.
The CPC ensures correct chromosome alignment and segregation, and is required for chromatin-induced microtubule stabilization and spindle assembly.
It plays a crucial role in cytokinesis, phosphorylating multiple substrates such as CHMP4C, INCENP, BIRC5, CDCA8, and histone H3.
Aurora kinases are essential for proper kinetochore localization, spindle formation, and cytokinesis checkpoint regulation.
Phosphorylation of p53/TP53 negatively regulates transcriptional activity, and AURKB acts as a key regulator of active promoters in resting B- and T-lymphocytes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(원본 이미지 파일명 참조)
- MA5-37152_Aurora_ABC_O14965-1_Rabbit.svg
- MA5-37152_Aurora_ABC_Q96GD4-1_Rabbit.svg
- MA5-37152_Aurora_ABC_Q9UQB9-1_Rabbit.svg
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