Thermo Fisher Scientific p19ARF Monoclonal Antibody (5-C3-1)
p19ARF 단백질을 인식하는 Rat monoclonal 항체로, Western blot, IHC, ICC, Flow cytometry, IP 등 다양한 응용에 사용 가능. Human, Mouse, Rat 반응성. Protein A 정제, PBS buffer, 0.05% sodium azide 포함. 암 억제 단백질 연구용에 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (IHC) | – |
| Immunohistochemistry (Paraffin) (IHC (P)) | 5 µg/mL |
| Immunohistochemistry (Frozen) (IHC (F)) | 5 µg/mL |
| Immunocytochemistry (ICC/IF) | 1:500–1:1,000 |
| Flow Cytometry (Flow) | 1 µg/mL |
| Immunoprecipitation (IP) | 1:10–1:500 |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Mouse |
| Host / Isotype | Rat / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 5-C3-1 |
| Immunogen | Synthetic peptide containing amino acids 54–75 of the murine p19ARF |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_568665 |
Product Specific Information
- This antibody does not react with human or Golden hamster.
- Armenian hamster has not been tested.
Target Information
The multiple tumor suppressor 1 locus (MTS1) encodes two unrelated genes, p16INK4a and p19ARF. Both act as cell proliferation inhibitors but through different mechanisms.
p19ARF functions in a p53-dependent pathway to counteract uncontrolled proliferation and oncogenic signals. Mice lacking the p19ARF gene rapidly develop a broad spectrum of tumors, indicating its critical role as a tumor suppressor.
Additionally, p19ARF prevents transforming signals from various oncoproteins through the p53 regulatory loop, highlighting its importance in cell cycle control and tumor suppression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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