Thermo Fisher Scientific MMP2 Monoclonal Antibody (MMP2/2C1)
MMP2 단백질을 인식하는 마우스 단클론 항체로, Western blot, IHC, ELISA 등 다양한 응용에 사용 가능. 사람, 마우스, 랫트, 기니피그에 반응. Protein G 정제, PBS 버퍼에 0.02% sodium azide 포함. 연구용으로 조직 재형성과 관련된 MMP2 연구에 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 2–5 µg/mL |
| Immunohistochemistry (Paraffin) (IHC-P) | 5 µg/mL |
| Immunohistochemistry (Frozen) (IHC-F) | 5 µg/mL |
| Immunocytochemistry (ICC/IF) | Assay-dependent |
| Flow Cytometry (Flow) | Assay-dependent |
| ELISA | 1 µg/mL |
| Immunoprecipitation (IP) | 1:10–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Guinea pig, Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | MMP2/2C1 |
| Immunogen | Activated recombinant human MMP-2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.0 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_568620 |
Product Specific Information
- Not recommended for immunohistochemistry on paraffin-embedded sections.
- Suggested positive control: lung, nerve, and various tumors.
Target Information
Matrix metalloproteinases (MMPs) are proteolytic enzymes that degrade connective tissue components. They share a conserved activation mechanism and are inhibited by tissue inhibitors of metalloproteinases (TIMPs). MMPs and TIMPs are key regulators of angiogenesis.
MMP2 is synthesized as a 631 amino acid proenzyme, activated by cleavage of the first 80 amino acids, and contains propeptide, catalytic, and hemopexin domains. MMPs can degrade extracellular matrix components such as collagens, fibronectin, laminin, and basement membrane glycoproteins. Structurally, MMPs include a signal peptide, propeptide, and catalytic domain with a conserved zinc-binding site.
Functionally, MMP2 is involved in tissue remodeling. Mutations in the MMP2 gene are associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Two transcript variants encoding different isoforms of MMP2 have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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