Thermo Fisher Scientific THRB Polyclonal Antibody
THRB 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot, IHC, ICC/IF, ChIP 등 다양한 응용에 사용 가능. Human, Mouse, Rat 반응성. 항원 친화 크로마토그래피로 정제되었으며, 4°C 단기 보관 및 -20°C 장기 보관 권장.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:3,000 | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | - | 1 publication |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 | - |
| ChIP assay (ChIP) | - | 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to a region within amino acids 1–199 of Human Thyroid Hormone Receptor beta |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.76 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.1M Tris glycine, pH 7, with 10% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C (short term). For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2493188 |
Product Specific Information
- Recommended positive controls: 293T, A431, H1299, HeLa, HepG2, Molt-4, Raji
- Predicted reactivity: Mouse (93%), Rat (92%), Sheep (90%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Thyroid hormone receptors (TR), also known as c-erbA-2, are ligand-dependent intracellular proteins that regulate transcription by binding to hormone response elements upon activation by thyroid hormones. These receptors influence metabolic processes, growth, and development by controlling gene expression for growth hormone, malic enzyme, and hepatic proteins.
There are two main forms of TR: TR alpha (chromosome 17) and TR beta (chromosome 3), each with two isoforms (TRα1/α2, TRβ1/β2). TRvα2, a non-T3-binding variant, acts as a strong negative regulator. The gene encoding thyroid hormone receptor beta-1 is NR1A2.
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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