Thermo Fisher Scientific CEP78 Polyclonal Antibody
Human CEP78 단백질을 인식하는 Rabbit Polyclonal 항체로, IHC(P)에서 1:500–1:1,000 희석 비율로 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, PBS(40% glycerol) buffer에 보관. 세포주기 및 섬모 형성과 관련된 CEP78 연구용.
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human CEP78. Recombinant protein control fragment (Product # RP-92996) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2639696 |
Product Specific Information
Immunogen sequence:
ALETNTTLVV LDIRKNPLID HSMMKAVIKK VLQNGRSAKS EYQWITSPSV KEPSKTAKQK RRTIILGSGH KGKATIRIGL ATKKPVSSGR K
Highest antigen sequence identity to orthologs:
- Mouse: 87%
- Rat: 84%
Target Information
The CEP78 gene encodes a centrosomal protein essential for regulating centrosome-related events during the cell cycle and for ciliogenesis. The protein contains an N-terminal leucine-rich repeat (LRR) domain with six consecutive LRR repeats and a C-terminal coiled-coil domain. It interacts with the N-terminal catalytic domain of polo-like kinase 4 (PLK4) and colocalizes with PLK4 at the distal end of the centriole.
Mutations in this gene cause primary cilia defects leading to retinal degeneration and sensorineural hearing loss, associated with cone-rod degeneration and Usher syndrome. Low expression of CEP78 correlates with poor prognosis in colorectal cancer patients.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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