Thermo Fisher Scientific CEP78 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:500-1:1,000

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human CEP78. Recombinant protein control fragment (Product #RP-92996). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:CEP78,uniProtId:Q5JTW2-1,ncbiNodeId:9606,antigenRange:279-369,antigenLength:689,antigenImageFileName:PA5-61823_CEP78_Q5JTW2-1_Rabbit.svg,antigenImageFileNamePDP:PA5-61823_CEP78_Q5JTW2-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.2 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2639696

Product Specific Information

Immunogen sequence: ALETNTTLVV LDIRKNPLID HSMMKAVIKK VLQNGRSAKS EYQWITSPSV KEPSKTAKQK RRTIILGSGH KGKATIRIGL ATKKPVSSGR K

Highest antigen sequence identity to the following orthologs: Mouse - 87%, Rat - 84%.

Target Information

This gene encodes a centrosomal protein that is both required for the regulation of centrosome-related events during the cell cycle, and required for ciliogenesis. The encoded protein has an N-terminal leucine-rich repeat (LRR) domain with six consecutive LRR repeats, and a C-terminal coiled-coil domain. It interacts with the N-terminal catalytic domain of polo-like kinase 4 (PLK4) and colocalizes with PLK4 to the distal end of the centriole. Naturally occurring mutations in this gene cause defects in primary cilia that result in retinal degeneration and sensorineural hearing loss which are associated with cone-rod degeneration disease as well as Usher syndrome. Low expression of this gene is associated with poor prognosis of colorectal cancer patients.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.