Thermo Fisher Scientific PDCD1 Monoclonal Antibody (OTI8B1), TrueMAB

Applications and Tested Dilutions

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform desalting prior to use (recommended: Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

Cell-mediated immune responses are initiated by T lymphocytes stimulated by peptides bound to MHC molecules on antigen-presenting cells (APCs).
Activated T cells express receptors such as PD-1 (PDCD-1), which mediate inhibitory signals from APCs. PD-1 binds to ligands PDL-1 and PDL-2, generating inhibitory signals that suppress immune activation in the absence of “danger signals” such as bacterial LPS.
PD-1 deficiency (PD1⁻/⁻ mice) results in hyperactivated immune systems and autoimmune conditions. Despite its predicted molecular weight, PD-1 often migrates at a higher molecular weight in SDS-PAGE.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.