Thermo Fisher Scientific MMP2 Monoclonal Antibody (OTI4A11), TrueMAB

Applications

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

Matrix metalloproteinases (MMPs) are proteolytic enzymes that degrade connective tissue components. They share a conserved activation mechanism and a metal-binding active site region and are inhibited by tissue inhibitors of metalloproteinases (TIMPs).
MMP2 is synthesized as a 631 amino acid proenzyme, activated by cleavage of the first 80 amino acids, and includes propeptide, catalytic, and hemopexin domains.
MMP2 plays a crucial role in tissue remodeling, and mutations in the MMP2 gene are associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome.
Two transcript variants encoding different isoforms of MMP2 have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.