Thermo Fisher Scientific PDCD1 Monoclonal Antibody (OTI4E5), TrueMAB

Applications and Tested Dilutions

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step (recommended: Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

Cell-mediated immune responses are initiated by T lymphocytes stimulated by peptides bound to MHC molecules on antigen-presenting cells (APC).
Activated T cells express inhibitory receptors such as PD-1 (PDCD-1), which bind ligands PDL-1 and PDL-2 to downregulate immune activation.
In the absence of “danger signals”, PD-1 signaling suppresses immune responses, preventing autoimmunity.
PD-1 often migrates at a higher molecular weight than predicted in SDS-PAGE.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.