Thermo Fisher Scientific RHOV Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.
• The antigen is homologous in rat and mouse.
• Specificity: RhoV.

Target Information

The Rho subfamily of Ras-related GTPases controls multiple aspects of cell function, including cytoskeletal rearrangement, nuclear signaling, and cell growth.
Rho V (ras homolog gene family, member V), also known as Rho GTPase-like protein ARHV, CHP, or WRCH2 (Wnt-1 responsive Cdc42 homolog 2), is a 236 amino acid protein that controls the actin cytoskeleton through activation of the JNK pathway.

As a member of the Rho family and small GTPase superfamily, Rho V functions as a lipid anchor at the cytoplasmic side of the cell membrane and is expressed in placenta, pancreas, and fetal brain.
Rho V is implicated in cell transformation and is encoded by a gene located on human chromosome 15, which houses over 700 genes and comprises nearly 3% of the human genome.
Chromosome 15-localized gene defects are associated with Angelman syndrome, Prader-Willi syndrome, Tay-Sachs disease, and Marfan syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.