Thermo Fisher Scientific Amyloid Precursor Protein Polyclonal Antibody
Thermo Fisher Scientific의 Amyloid Precursor Protein Polyclonal Antibody는 인간, 마우스, 랫트 등 다양한 종에 반응하며 Western blot, IHC, ICC/IF에 적합합니다. APP 단백질 연구용으로 고순도 항원 친화 크로마토그래피 정제 제품입니다. Alzheimer 연구에 활용됩니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to amino acids 602–770 of beta Amyloid (Uniprot ID: P05067) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 10% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C avoiding freeze/thaw cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2552009 |
Product Specific Information
- Recommended positive controls: HepG2, NIH-3T3, U87-MG, SK-N-SH, IMR32, SK-N-AS
- Predicted reactivity: Mouse (97%), Rat (97%), Xenopus laevis (93%), Dog (100%), Pig (100%), Rabbit (100%), Chicken (98%), Chimpanzee (100%), Bovine (100%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Amyloid Precursor Protein (APP), also known as Amyloid beta precursor protein, functions as a cell surface kinesin I membrane receptor mediating axonal transport of beta-secretase and presenilin 1. APP is crucial for neurite growth, neuronal adhesion, and axonogenesis. It is a 100–140 kDa transmembrane glycoprotein existing as several isoforms due to alternative splicing. Proteolytic cleavage of APP by beta- and gamma-secretases generates beta amyloid, the main component of senile plaques—a hallmark of Alzheimer’s disease. Abnormal regulation and processing of APP are implicated in Down’s syndrome, early onset familial Alzheimer’s disease, and cerebral hemorrhage.
⚠ WARNING: This product can expose you to chemicals including mercury, known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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