Thermo Fisher Scientific NRG1 Polyclonal Antibody
NRG1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot 및 Immunocytochemistry에 적합하며, 인간·마우스·랫트 반응성. 고순도 항원 친화 크로마토그래피 정제, 액상 형태로 제공. 연구용으로만 사용.
- 카탈로그번호
- PA534648
- 판매단위
- pk
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Thermo Fisher Scientific NRG1 Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein fragment corresponding to amino acids 1–211 (Q02297) of NRG1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.96 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.1M Tris glycine, pH 7, with 10% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2552000 |
Product Specific Information
- Recommended positive controls: Human brain, Mouse brain, Rat brain
- Predicted reactivity: Rat (97%), Bovine (91%)
- Store as a concentrated solution. Centrifuge briefly before opening the vial.
Target Information
Neuregulin 1 (NRG1) is a 44-kDa glycoprotein that interacts with the NEU/ERBB2 receptor tyrosine kinase, increasing its phosphorylation on tyrosine residues. Multiple isoforms are produced by alternative splicing, including heregulins (HRGs), glial growth factors (GGFs), and sensory/motor neuron-derived factor (SMDF).
These isoforms differ structurally and are tissue-specifically expressed:
- HRG isoforms contain Ig and EGF-like domains
- GGF isoforms contain kringle-like, Ig, and EGF-like domains
- SMDF isoform shares only the EGF-like domain
NRG1 isoforms interact with ERBB family receptors to induce growth and differentiation of epithelial, neuronal, glial, and other cell types.
Safety Information
⚠ WARNING: This product can expose you to chemicals including mercury, known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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