Thermo Fisher Scientific RFXANK Monoclonal Antibody (OTI2G7), TrueMAB

Applications and Tested Dilution

Product Specifications

Product Specific Information

For reconstitution, add 100 µL of distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

Major histocompatibility (MHC) class II molecules are transmembrane proteins essential for immune system regulation.
The RFXANK protein, together with regulatory factor X-associated protein and regulatory factor-5, forms a complex that binds to the X box motif of MHC class II gene promoters, activating transcription.
This complex interacts with the MHC class II transactivator (CIITA), which determines cell type specificity and inducibility of MHC class II expression.
RFXANK contains ankyrin repeats involved in protein-protein interactions.
Mutations in this gene are associated with bare lymphocyte syndrome type II, complementation group B.
Two transcript variants encoding different isoforms have been described, with only one showing activation activity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.