Thermo Fisher Scientific CDK1 Monoclonal Antibody (POH-1)
CDK1 단백질을 인식하는 고특이성 마우스 단클론 항체로 세포 증식 및 분열 연구에 적합. Western blot, IHC, ICC, IP 등 다양한 응용 가능. 인간 및 비인간 영장류 반응성. Protein A 정제, 4°C 보관.
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Thermo Fisher Scientific CDK1 Monoclonal Antibody (POH-1)
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1–2 µg/mL | View 5 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | 10 µg/mL | - |
| Immunocytochemistry (ICC/IF) | Assay-dependent | View 1 publication |
| Immunoprecipitation (IP) | Assay-dependent | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Bovine, Human, Non-human primate |
| Published Species | Bovine, Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | POH-1 |
| Immunogen | Bacterially expressed full-length human Cdk1 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 15 mM sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1075472 |
Product Specific Information
This antibody detects Cdk1 (p34Cdc2; an intracellular antigen).
Staining of Cdk1 reflects the proliferating potential of respective tissue.
This antibody will not cross-react with Drosophila, mouse, Xenopus, or rat.
Target Information
CDK1 (Cell Division Control protein 1) is essential for the completion of START, the controlling event in the cell cycle required to initiate mitosis.
It acts as the catalytic subunit of the M-Phase Promoting Factor (MPF), which induces entry into mitosis and is conserved among eukaryotes.
Phosphorylation of Bcl-2 in G2/M phase-arrested cells following photodynamic therapy with hypericin involves a CDK1-mediated signal that delays apoptosis.
Therapeutic potential of CDK inhibitor NU2058 in androgen-independent prostate cancer has also been demonstrated.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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