Thermo Fisher Scientific hCG beta Monoclonal Antibody (HCG-61)

Applications

Immunocytochemistry (ICC/IF)

• Tested Dilution: Assay-dependent

ELISA

• Tested Dilution: Assay-dependent

Product Specifications

Product Specific Information

This antibody reacts with association constant 5.1 × 10¹⁰ l/mol.
Cross-reactivity (%) determined by double-antibody RIA using unlabeled hormones:

• beta-hCG: 77%
• alpha-hCG: 1.3%
• hLH: 0.86%
• hFSH: < 0.5%
• hTSH: < 0.5%

Target Information

hCG beta is the beta chain of Human chorionic gonadotropin (hCG), a 40 kDa glycoprotein hormone produced by trophoblastic cells of the placenta beginning 10–12 days after conception.
hCG consists of alpha and beta subunits that are non-covalently associated. The alpha subunit is similar to those of pituitary hormones (FSH, LH, TSH), while the beta subunit confers biological specificity.

During early pregnancy, hCG stimulates the corpus luteum to produce progesterone, maintaining the secretory endometrium.
In non-pregnant individuals, hCG is present only in trace amounts but rises sharply during pregnancy.

Diseases associated with hCG dysfunction include gestational trophoblastic tumor and hydatidiform mole.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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