Thermo Fisher Scientific Galectin 3 Monoclonal Antibody (eBioM3/38 (M3/38)), PE, eBioscience
Galectin-3 단백질을 검출하는 PE 결합 Rat 모노클론 항체로, Flow Cytometry 및 면역형광 분석에 적합합니다. Human 및 Mouse 반응성을 가지며, 0.06 µg/test로 최적화되어 있습니다. 염증 및 세포 분화 연구에 유용한 고품질 연구용 항체입니다.
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Thermo Fisher Scientific Galectin 3 Monoclonal Antibody (eBioM3/38 (M3/38)), PE, eBioscience™
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Immunocytochemistry (ICC/IF) | - | View 1 publication |
| Flow Cytometry (Flow) | 0.06 µg/test | View 4 publications |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Hamster, Human, Mouse |
| Host / Isotype | Rat / IgG2a, kappa |
| Recommended Isotype Control | Rat IgG2a kappa Isotype Control (eBR2a), PE, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | eBioM3/38 (M3/38) |
| Conjugate | PE |
| Excitation / Emission Max | 565 / 576 nm |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_842792 |
Additional Formats
- Unconjugated
- Biotin
- eFluor 660
- Request custom conjugation
Product Specific Information
The eBioM3/38 antibody reacts with mouse Galectin-3 (Mac-2). Galectins are a family of animal lectins exhibiting diverse biological functions. Galectin 3 (LGALS3, Mac-2, L-29) is a 30 kDa beta-galactoside-binding protein with a C-terminal carbohydrate-binding site, capable of binding IgE and mammalian cell surfaces when homodimerized or homo-oligomerized.
Galectin 3 is distributed in epithelia and inflammatory cells (macrophages, dendritic cells, Kupffer cells). Expression is up-regulated during inflammation, cell proliferation, differentiation, and by viral trans-activation.
This monoclonal antibody eBioM3/38 cross-reacts with human Galectin-3 (LGALS3).
Applications Reported: Flow cytometric analysis.
Applications Tested: Tested on mouse thioglycolate-elicited peritoneal macrophages. Recommended ≤ 0.06 µg/test (100 µL volume). Cell count range: 10⁵–10⁸ cells/test. Optimize titration for best performance.
Optical Properties:
Excitation: 488–561 nm
Emission: 578 nm
Compatible Lasers: Blue, Green, Yellow-Green
Filtration: 0.2 µm post-manufacturing filtered.
Target Information
Galactose-specific lectin binding IgE. Mediates endothelial cell migration via alpha-3, beta-1 integrin and CSPG4. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis. Functions as a pre-mRNA splicing factor in the nucleus. Involved in acute inflammatory responses, including neutrophil activation, monocyte/macrophage chemoattraction, opsonization of apoptotic neutrophils, and mast cell activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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