Thermo Fisher Scientific IRF7 Monoclonal Antibody (RDP4ND4), PE, eBioscience
인간 IRF7 단백질을 인식하는 단클론 항체로, PE 형광표지되어 유세포분석(Flow Cytometry)에 적합합니다. 항바이러스 면역 반응 연구에 활용되며, 4°C 암소 보관이 필요합니다. 친화 크로마토그래피로 정제된 고품질 연구용 시약입니다.
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Applications and Tested Dilution
Flow Cytometry (Flow)
- Tested Dilution: 5 µL (0.125 µg)/test
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rat / IgG2a, kappa |
| Recommended Isotype Control | Rat IgG2a kappa Isotype Control (eBR2a), PE, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | RDP4ND4 |
| Conjugate | PE |
| Excitation/Emission Max | 565 / 576 nm |
| Form | Liquid |
| Concentration | 5 µL/Test |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 0.2% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE! |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2716928 |
Available Formats
Product Specific Information
The monoclonal antibody RDP4ND4 recognizes human interferon regulatory factor 7 (IRF7), a 54 kDa transcription factor essential for antiviral innate immune response and activation of type I IFN genes. IRF7 is constitutively expressed in plasmacytoid dendritic cells, B cells, and monocytes, and is strongly induced upon viral infection or interferon stimulation.
IRF7 activates IFN-β and IFN-α genes via virus-activated (MyD88-independent) or TLR-activated (MyD88-dependent) pathways. Upon virus exposure, IRF7 is induced through TLR7, TLR8, and TLR9, promoting IFN gene expression. Phosphorylation of IRF7 triggers dimerization and nuclear translocation, enabling activation of target genes. Expression is upregulated by interferon through the Jak-STAT pathway in a positive feedback loop.
Applications Reported: Flow cytometric analysis.
Applications Tested: Pre-diluted and tested for flow cytometry using stimulated normal human peripheral blood cells with the Foxp3/Transcription Factor Staining Buffer Set (Product #00-5523-00) and protocol.
Recommended protocol: BestProtocols® – Protocol B: One-step protocol for nuclear intracellular proteins.
- Recommended use: 5 µL (0.125 µg) per test
- A test is defined as antibody amount for staining a 100 µL final volume sample
- Cell number: 10⁵–10⁸ cells/test (empirically determined)
- Excitation: 488–561 nm
- Emission: 578 nm
- Compatible lasers: Blue, Green, Yellow-Green
Target Information
Interferons (IFNs) play key roles in antiviral immune regulation. IRF7 functions as a transcriptional activator of virus-inducible genes, including interferon beta. It interacts with TLR adaptor proteins (MyD88, Tirp/TRAM) and mediates TLR4 and TLR9 signaling. Multiple spliced isoforms of IRF7 exist, though their specific functions remain unclear.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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