Thermo Fisher Scientific LIMK2 Polyclonal Antibody

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:50–1:200

Product Specifications

Product Specific Information

Immunogen sequence:
VEEVEDAISQ TSQTLQLLIE HDPVSQRLDQ LRLEARLAPH MQNAGHPHAL STLDTKENLE GTLRRRSLRR SNSISKSPGP SSPKEPLLFS RDISRSESLR CSSSYSQ

Target Information

LIMK2 is a serine/threonine kinase involved in regulation of actin cytoskeletal changes via phosphorylation of cofilin. LIMK2 has also been implicated in brain development. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of two N-terminal LIM motifs and a C-terminal protein kinase domain. The protein encoded by LIMK2 is phosphorylated and activated by ROCK, a downstream effector of Rho, and in turn phosphorylates cofilin, inhibiting its actin-depolymerizing activity. This pathway contributes to Rho-induced reorganization of the actin cytoskeleton. At least three transcript variants encoding different isoforms have been found for LIMK2.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.