Thermo Fisher Scientific NPDC1 Polyclonal Antibody
인간 NPDC1 단백질을 인식하는 Rabbit Polyclonal 항체입니다. IHC(P) 및 ICC/IF에 사용 가능하며, 항원 친화 크로마토그래피로 정제되었습니다. PBS(glycerol 포함) 용액 형태로 제공되며, 단기 4°C, 장기 -20°C 보관이 권장됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:20–1:50 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human NPDC1. Recombinant protein control fragment (Product #RP-89897) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2789497 |
Product Specific Information
Immunogen sequence:
CWCRLQREIR LTQKADYATA KAPGSPAAPR ISPGDQRLAQ SAEMYHYQHQ RQQMLCLERH KEPPKELDTA SSDEENEDGD FTVYECPGLA PTGEMEVRNP LFDHAALSAP LPAPSSPPAL P
Target Information
The discovery of NPDC-1 (neuronal proliferation, differentiation and control protein 1) was the result of a study of genes that were preferentially expressed in immortalized neural precursor cell lines at the onset of contact inhibition of proliferation and subsequent differentiation. Transfection of transformed cells with NPDC-1 led to increased doubling times and suppression of many characteristics of transformation. NPDC-1 is differentially expressed in brain and lung and interacts directly with transcription factor E2F-1, D-type cyclins, and cdk2. It acts as a modulator of transcriptional events mediated by retinoic acid, and its protein level and activity are regulated by phosphorylation-mediated proteasomal degradation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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