Thermo Fisher Scientific Ephrin B3 Polyclonal Antibody
Ephrin B3 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체로, WB, IHC(P), ICC/IF 등에 사용 가능. 인간 시료에 반응하며, 고순도의 친화 크로마토그래피 정제 제품. 뇌 발달 관련 연구에 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human EFNB3 (Accession Q15768), corresponding to amino acid residues A231–G281 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2818552 |
Product Specific Information
Antibody detects endogenous levels of total Ephrin-B3.
Target Information
EFNB3, a member of the ephrin gene family, plays an important role in brain development and maintenance. EFNB3 expression is particularly high in several forebrain subregions, suggesting a pivotal role in forebrain function.
The EPH and EPH-related receptors form the largest subfamily of receptor protein-tyrosine kinases, mediating developmental events in the nervous system.
EPH receptors typically contain a single kinase domain and an extracellular region with a Cys-rich domain and two fibronectin type III repeats.
Ephrins are classified into ephrin-A (EFNA) and ephrin-B (EFNB) classes:
- Ephrin-A (EFNA): Anchored to the membrane by a glycosylphosphatidylinositol linkage
- Ephrin-B (EFNB): Transmembrane proteins
The Eph family of receptors are similarly divided into two groups based on extracellular domain sequence similarity and ligand-binding affinity.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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