Thermo Fisher Scientific LSD1 Monoclonal Antibody (1B2E5)
LSD1 단백질을 인식하는 Mouse Monoclonal 항체로, Western blot, IHC, ICC, IP 등 다양한 응용에 적합합니다. Human, Mouse 등 여러 종에 반응하며, Protein A로 정제된 고순도 항체입니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–3 µg/mL |
| Immunohistochemistry (Paraffin) (IHC-P) | 5–10 µg/mL |
| Immunocytochemistry (ICC/IF) | 1:100 |
| Immunoprecipitation (IP) | 5 µg |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Bovine, Dog, Human, Mouse, Non-human primate, Rat |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 1B2E5 |
| Immunogen | Recombinant protein derived from the internal region of human LSD1 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.1% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2533503 |
Target Information
LSD1 is a histone demethylase that specifically demethylates Lys-4 of histone H3, a mark associated with epigenetic transcriptional activation, thereby acting as a corepressor. It contains a SWIRM domain, a FAD-binding motif, and an amine oxidase domain. LSD1 is a component of several histone deacetylase complexes and silences genes by functioning as a histone demethylase. The enzyme oxidizes its substrate via FAD to generate an imine intermediate that is hydrolyzed. LSD1 demethylates both mono- and tri-methylated Lys-4 of histone H3 and may play a role in repression of neuronal genes. It requires RCOR1/CoREST for nucleosomal H3 Lys-4 demethylation activity. LSD1 may also demethylate Lys-9 of histone H3, leading to derepression of androgen receptor target genes. Mutations in this gene can result in cleft palate, psychomotor retardation, and distinctive facial features.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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