Thermo Fisher Scientific EB1 Monoclonal Antibody (1A11/4)
EB1 단백질을 인식하는 Thermo Fisher의 Mouse Monoclonal 항체로, WB, ICC/IF, ELISA 등 다양한 응용에 적합. Human, Mouse, Rat, Dog 반응성. Protein A로 정제된 액상 형태이며, 안정적인 PBS 버퍼에 보존. 연구용으로 세포골격 및 미세소관 관련 연구에 활용 가능.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1–3 µg/mL | View 2 publications |
| Immunocytochemistry (ICC/IF) | Assay-dependent | View 2 publications |
| ELISA | Assay-dependent | – |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Dog, Human, Mouse, Rat |
| Published Species | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 1A11/4 |
| Immunogen | Recombinant protein encompassing the N-terminal domain of the human EB1 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.1% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2533500 |
Target Information
EB1 family proteins are evolutionarily conserved proteins that bind microtubule plus-ends and centrosomes and regulate the dynamics and organization of microtubules. The MAPRE genes encode the EB1 family proteins. The human MAPRE genes MAPRE1, MAPRE2, and MAPRE3 code for EB1, RP1, and EBF3 proteins, respectively.
EB1 family members appear to be expressed ubiquitously. The EB1 (MAPRE1) gene, at 20q11.2, is fused to MLL in an adult patient with pro-B acute lymphoblastic leukemia. EB1 is a microtubule-associated protein that interacts with the colorectal adenomatous polyposis coli tumor-suppressor protein and plays important roles in regulating microtubule dynamics, cell polarity, and chromosome stability.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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