Thermo Fisher Scientific CD86 Monoclonal Antibody (GL-1)

Applications and Tested Dilution

Product Specifications

Additional Formats

• FITC Conjugate
• Request Custom Conjugation

Product Specific Information

This antibody reacts with an extracellular epitope of CD86 (B7-2), a 70–80 kDa type I transmembrane glycoprotein of the immunoglobulin superfamily. CD86 is expressed on professional antigen-presenting cells such as dendritic cells, macrophages, and activated B lymphocytes.
Functional Application: Blocking.

Target Information

CD86 is one of two ligands (the other being CD80) for CTLA4 and CD28. It acts as a costimulatory molecule in eliciting T-cell help during antigen presentation. In the absence of sufficient co-stimulation involving CD86/CD80, antigen presentation can induce tolerance. CD86 is a type I membrane protein and a member of the immunoglobulin superfamily, expressed by antigen-presenting cells. It binds to CD28 antigen and cytotoxic T-lymphocyte-associated protein 4 (CTLA4) on T cells.

• Binding with CD28 provides a costimulatory signal for T-cell activation.
• Binding with CTLA4 negatively regulates T-cell activation and diminishes immune response.

Alternative splicing results in two transcript variants encoding different isoforms of CD86. Additional transcript variants have been described, though their full-length sequences remain undetermined.
Diseases associated with CD86 dysfunction include gallbladder squamous cell carcinoma and myocarditis.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.