
Thermo Fisher Scientific CD8 beta Monoclonal Antibody (341)
Rat CD8β 단백질을 인식하는 마우스 단일클론 항체로, 세포표면 CD8 코리셉터의 β사슬을 검출합니다. Western blot, IHC(F), Flow cytometry, IP 등에 사용 가능하며, 1 mg/mL 농도의 액상 형태로 제공됩니다. 연구용으로만 사용됩니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-Dependent |
| Immunohistochemistry (Frozen) (IHC (F)) | Assay-Dependent |
| Flow Cytometry (Flow) | 1.5 µg/mL |
| Immunoprecipitation (IP) | Assay-Dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Rat |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 341 |
| Immunogen | CD8 positive Wistar rat splenic T cell hybridomas |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 15 mM sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11153985 |
Additional Formats
Product Specific Information
This antibody recognizes rat CD8b, the 32–34 kDa beta chain of the CD8 coreceptor (extracellular epitope), expressed on T cell subsets and some other cell types, such as macrophages.
Target Information
The CD8B antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen, acting as a coreceptor together with the T-cell receptor, recognizes antigens displayed by antigen presenting cells (APCs) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology with immunoglobulin variable light chains. This gene encodes the CD8 beta chain isoforms. Multiple alternatively spliced transcript variants encoding distinct membrane-associated or secreted isoforms have been described. A pseudogene located on chromosome 2 has also been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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