Thermo Fisher Scientific DNMT3B Polyclonal Antibody

Thermo Fisher Scientific DNMT3B Polyclonal Antibody

Applications

• Western Blot (WB): 1:500–1:3,000

Product Specifications

Product Specific Information

• Recommended positive control: Recombinant DNMT3B protein
• Predicted reactivity: Human (94%), Mouse (100%), Rat (99%), Pig (95%), Bovine (95%)
• Store as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

CpG methylation is an epigenetic modification important for embryonic development, imprinting, and X-chromosome inactivation. DNA methylation is essential for mammalian development.
This gene encodes a DNA methyltransferase involved in de novo methylation, primarily localized to the nucleus and developmentally regulated.
Mutations in DNMT3B cause ICF syndrome (Immunodeficiency-Centromeric Instability-Facial anomalies). Six alternatively spliced transcript variants have been described, though full-length sequences of variants 4 and 5 have not been determined.

⚠ WARNING: This product can expose you to chemicals including mercury, known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.