Thermo Fisher Scientific DNMT3B Polyclonal Antibody
DNMT3B 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot에 적합하며 인간 및 생쥐에 반응. 항원 친화 크로마토그래피로 정제된 액상 형태. DNMT3B 관련 발달 및 후성유전학 연구에 활용 가능.
- 카탈로그번호
- PA532218
- 판매단위
- pk
카탈로그
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Thermo Fisher Scientific DNMT3B Polyclonal Antibody
Applications
- Western Blot (WB): 1:500–1:3,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein fragment corresponding to amino acids 601–889 of Mouse DNMT3B |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 20% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2549691 |
Product Specific Information
- Recommended positive control: Recombinant DNMT3B protein
- Predicted reactivity: Human (94%), Mouse (100%), Rat (99%), Pig (95%), Bovine (95%)
- Store as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
CpG methylation is an epigenetic modification important for embryonic development, imprinting, and X-chromosome inactivation. DNA methylation is essential for mammalian development.
This gene encodes a DNA methyltransferase involved in de novo methylation, primarily localized to the nucleus and developmentally regulated.
Mutations in DNMT3B cause ICF syndrome (Immunodeficiency-Centromeric Instability-Facial anomalies). Six alternatively spliced transcript variants have been described, though full-length sequences of variants 4 and 5 have not been determined.
⚠ WARNING: This product can expose you to chemicals including mercury, known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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