Thermo Fisher Scientific Influenza A PA Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Recommended positive controls: Influenza virus (A/WSN/1933(H1N1))-infected DF-1 cell lysates.
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

Influenza viruses consist of three types (Influenza A, B, and C), which make up three of the five genera in the Orthomyxoviridae family. Commonly known as the flu, influenza strains can affect both birds and mammals. Influenza strains form roughly spherical particles and are similar in composition, with viral envelopes containing two main types of glycoproteins (hemagglutinin and neuraminidase), wrapped around the central core of the viral RNA genome and other viral proteins that package and protect the RNA.

Unusually for a virus, the influenza virus genome is not a single piece of nucleic acid; rather, it consists of seven to eight segmented fragments of negative-sense RNA, each expressing different viral proteins. Influenza spreads seasonally, resulting in about three to five million yearly cases of severe illness and about 250,000 to 500,000 deaths annually, or into the millions in pandemic years.

Influenza A virus contains eight single-stranded, negative-sense RNAs. Each RNA is associated with viral RNA-dependent RNA polymerase, which consists of PA, PB1, and PB2 proteins. Recent reports indicate the involvement of PA in the “cap-snatching” mechanism via its endonuclease activity, which is essential for cRNA-dependent viral RNA synthesis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.