Thermo Fisher Scientific HPV Type 16 E7 Recombinant Rabbit Monoclonal Antibody (HL1821)

Thermo Fisher Scientific HPV Type 16 E7 Recombinant Rabbit Monoclonal Antibody (HL1821)

Applications and Tested Dilution

• Western Blot (WB): Assay-dependent
• ELISA (ELISA): Assay-dependent
• Lateral Flow (LF): Assay-dependent

Product Specifications

Product Specific Information

This antibody can be used in Sandwich ELISA to detect HPV Type 16 E7 using MA5-47121 as the capture antibody and MA5-50337 as the detection antibody.

Target Information

HPV E7 proteins are small, zinc-binding phosphoproteins localized in the nucleus. HPV16 E7 consists of 98 amino acids (15 kDa) and is structurally and functionally similar to the E1A protein of subgenus C adenoviruses.
The first 16 N-terminal amino acids of HPV16 E7 contain a region homologous to the conserved region 1 (CR1) of E1A, while the next domain (up to amino acid 37) corresponds to region 2 (CR2). These domains are essential for cell transformation in vitro, suggesting a similar mechanism of transformation among these viruses.
The CR2 region includes the LXCXE motif (residues 22–26), which is involved in binding to the tumor suppressor protein pRb.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.