Thermo Fisher Scientific HSC70 Recombinant Rabbit Monoclonal Antibody (HL1788)
HSC70 단백질을 인식하는 Thermo Fisher Scientific의 재조합 Rabbit Monoclonal 항체입니다. Western blot 및 IHC(P) 등에 사용 가능하며, HEK293 세포에서 발현된 고순도 Protein A 정제 제품입니다. Human 및 Zebrafish에 반응하며, 장기 보관 시 -20°C에서 안정적으로 유지됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:5,000–1:30,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Zebrafish |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | HL1788 |
| Immunogen | Recombinant fragment of human HSC70 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3093908 |
Target Information
The HSP70 family comprises highly conserved proteins induced by various biological stresses, including heat shock, across all organisms studied. Human HSP70 family members include:
- HSP70: Strongly inducible and constitutively expressed in primate cells.
- HSP72: Induced exclusively under stress conditions (72 kDa).
- HSC70: Constitutively expressed (72 kDa), involved in uncoating clathrin-coated vesicles.
- GRP78 (BiP): Glucose-regulated 78 kDa protein localized in the endoplasmic reticulum.
- p75 (HSP75): 75 kDa mitochondrial protein.
HSC70 (also known as HSC71, HSC73, HSP73, p72, prp73) is constitutively expressed and slightly heat-inducible. It binds to the exposed loop of clathrin light chains to promote uncoating and can also bind the cytoskeleton to facilitate rearrangements. HSC70 has been shown to stimulate lysosomal degradation of intracellular proteins and retard aggregation and folding of mitochondrial precursor proteins in vitro.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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