Thermo Fisher Scientific MAP2K4 Recombinant Rabbit Monoclonal Antibody (HL1839)
MAP2K4 단백질을 표적하는 Thermo Fisher Scientific의 재조합 토끼 단클론 항체 HL1839. Western blot 및 IHC(P) 등 다양한 응용에 적합. HEK293 세포에서 발현된 IgG 형태로, 고순도 Protein A 정제. 단기 4°C, 장기 -20°C 보관 권장.
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Thermo Fisher Scientific MAP2K4 Recombinant Rabbit Monoclonal Antibody (HL1839)
Applications
- Western Blot (WB): Assay-dependent
- Immunohistochemistry (Paraffin) (IHC (P)): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | HL1839 |
| Immunogen | Recombinant fragment of human SEK1/MKK4 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3093829 |
Target Information
MAP2K4 (MEK4) serine/threonine kinase (mitogen-activated protein kinase 4) MEK4 or MKK4 is a dual specificity kinase of the STE7 family that phosphorylates and activates JNK1 and JNK2, as well as p38. MAP2K4 preferentially phosphorylates the tyrosine residue of JNKs.
MAP2K4 mediates various physiological and pathophysiological processes such as responses to cellular stresses and inflammatory cytokines. It is important for carcinogenesis; a loss-of-function mutation in MAP2K4 has been found in lung and pancreatic tumors. Conversely, a pro-oncogenic role was also identified for MAP2K4.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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