Thermo Fisher Scientific BCL-2 Polyclonal Antibody
BCL-2 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot, IHC, ICC/IF에 적합합니다. 인간, 마우스, 랫, 절지동물 시료에 반응하며, PBS와 글리세롤 버퍼에 보관됩니다. 세포 사멸 조절 연구용으로 적합합니다.
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- PA5114899
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Arthropod, Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human BCL2 (Accession P10415), corresponding to amino acid residues A45–L95 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20 °C |
| Shipping Conditions | Wet ice |
| RRID | AB_2899535 |
Product Specific Information
This antibody detects endogenous levels of total BCL-2 protein.
Target Information
BCL-2 is a key regulator of apoptosis that functions to either inhibit or promote cell death. Members of the BCL-2 family can dimerize to modulate apoptosis. For example, Bag1 forms a heterodimer with BCL-2 to enhance its anti-apoptotic effect. Bax and Bak promote cytochrome c release from mitochondria, initiating apoptosis. Overexpression or constitutive expression of BCL-2, such as translocation to the Ig heavy chain locus, is associated with follicular lymphoma. High BCL-2 expression is observed in neoplastic germinal centers of follicular lymphomas, while normal centers are negative. Two transcript variants exist, differing in the C-terminal region. Overexpression of BCL-2 has been linked to various human cancers, including B-cell lymphoma and prostate cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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