Thermo Fisher Scientific alpha-1 Antitrypsin Polyclonal Antibody
Human alpha-1 antitrypsin 단백질을 인식하는 다클론 항체로, Western blot과 ELISA에 적합합니다. Chicken IgY 기반 비결합형 항체이며, 1 mg/mL 농도의 액상 형태입니다. 단기 4°C, 장기 -20°C 보관 권장.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000–1:5,000 | View 1 publication |
| ELISA | 1:1,000–1:5,000 | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Mouse |
| Host / Isotype | Chicken / IgY |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Mix of synthetic peptides corresponding to residues 30–41 and 296–307 of human alpha-1 antitrypsin protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | IgY fraction |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2185300 |
Product Specific Information
PA1-9529 detects Alpha1 trypsin in human samples.
This antibody has been successfully used in Western blot and ELISA applications.
By Western blot, PA1-9529 detects a 46 kDa protein representing Alpha1 trypsin.
The immunogen is a synthetic peptide based on the human alpha-1 antitrypsin protein.
Target Information
Alpha-1 antitrypsin (Alpha-1-AT) is synthesized in the liver and functions as an inhibitor of proteases such as trypsin, elastase, chymotrypsin, collagenase, leucocytic proteases, plasmin, and thrombin, which may be released during inflammatory reactions in the lung.
In the absence of alpha-1-AT, these enzymes are not inhibited and may digest pulmonary parenchyma.
Alpha-1-AT deficiency is associated with chronic obstructive lung disease (emphysema) and, less frequently, with hepatic cirrhosis in infants and respiratory distress of the newborn.
An increase in alpha-1-AT occurs as an acute phase response to tissue necrosis and inflammation.
Serum levels of alpha-1-AT are elevated in rheumatoid arthritis, bacterial infections, vasculitis, and carcinomatosis.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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