Thermo Fisher Scientific alpha-1 Antitrypsin Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

PA1-9529 detects Alpha1 trypsin in human samples.
This antibody has been successfully used in Western blot and ELISA applications.
By Western blot, PA1-9529 detects a 46 kDa protein representing Alpha1 trypsin.
The immunogen is a synthetic peptide based on the human alpha-1 antitrypsin protein.

Target Information

Alpha-1 antitrypsin (Alpha-1-AT) is synthesized in the liver and functions as an inhibitor of proteases such as trypsin, elastase, chymotrypsin, collagenase, leucocytic proteases, plasmin, and thrombin, which may be released during inflammatory reactions in the lung.
In the absence of alpha-1-AT, these enzymes are not inhibited and may digest pulmonary parenchyma.
Alpha-1-AT deficiency is associated with chronic obstructive lung disease (emphysema) and, less frequently, with hepatic cirrhosis in infants and respiratory distress of the newborn.
An increase in alpha-1-AT occurs as an acute phase response to tissue necrosis and inflammation.
Serum levels of alpha-1-AT are elevated in rheumatoid arthritis, bacterial infections, vasculitis, and carcinomatosis.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.