Thermo Fisher Scientific Twist1/Twist2 Polyclonal Antibody
Twist1/Twist2 단백질을 인식하는 Thermo Fisher Scientific의 다클론 항체로, Western blot과 IHC에 적합합니다. 다양한 종(인간, 생쥐, 랫트 등)에 반응하며, 항원 친화 크로마토그래피로 정제되었습니다. 연구용으로만 사용 가능합니다.
- 카탈로그번호
- PA578211
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:10,000
- References: —
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:100–1:1,000
- References: —
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Fruit fly, Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein encompassing a sequence within the center region of human Twist1/2 (exact sequence proprietary) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.67 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 20% glycerol |
| Contains | 0.025% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2736761 |
Product Specific Information
- Positive Control: Raji, THP-1, HL-60, TWIST1-transfected 293T lysates, Jurkat, OECM1, CL1-5, Toledo, SU-DHL-5, HT, DB, RL95-2, MDA-MB-231
- Predicted Reactivity: Japanese Medaka (95%), Xenopus laevis (97%), Chicken (100%), Chimpanzee (100%), Bovine (100%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Twist1/Twist2 encodes a basic helix-loop-helix (bHLH) transcription factor important in embryonic development. The encoded protein forms homo- and heterodimers that bind to DNA E-box sequences, regulating genes involved in cranial suture closure during skull development. It may also influence neural tube closure, limb development, and brown fat metabolism. Twist1/Twist2 is hypermethylated and overexpressed in multiple human cancers, promoting tumor invasion and metastasis. Mutations in this gene cause Saethre-Chotzen syndrome, characterized by craniosynostosis, ptosis, and hypertelorism.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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