Thermo Fisher Scientific c-Mpl Polyclonal Antibody

Thermo Fisher Scientific c-Mpl Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• In direct ELISAs and Western blots, less than 1% cross-reactivity with recombinant human Epo R is observed.
• Reconstitute at 0.2 mg/mL in sterile PBS.
• Endotoxin level is <0.10 EU per 1 µg of the antibody by the LAL method.

Target Information

In 1990, an oncogene v-mpl was identified from the murine myeloproliferative leukemia virus that could immortalize bone marrow hematopoietic cells from different lineages.
In 1992, the human homologue c-mpl was cloned, revealing that it encodes a protein homologous to members of the hematopoietic receptor superfamily.
Anti-sense oligodeoxynucleotides of c-mpl inhibited megakaryocyte colony formation.
Its ligand, thrombopoietin, cloned in 1994, was shown to be the major regulator of megakaryocytopoiesis and platelet formation.

The c-mpl gene (CD110) encodes a 635 amino acid transmembrane protein with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs.
TPO-R deficient mice are severely thrombocytopenic, highlighting the importance of CD110 and thrombopoietin in platelet formation.
Upon thrombopoietin binding, CD110 dimerizes, activating JAK, STAT, MAPK, and Shc pathways through tyrosine phosphorylation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지

(이미지 파일은 본문 하단에 위치합니다)