Thermo Fisher Scientific Growth Hormone (Pituitary Marker) Recombinant Rabbit Monoclonal Antibody (GH/8136R)

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: Assay-dependent

Immunohistochemistry (PFA fixed) (IHC (PFA))

• Tested Dilution: 1–2 µg/mL

Product Specifications

Target Information

Human growth hormone (hGH) is a member of the somatotropin/prolactin family of hormones that play an important role in growth control.
The GH1 gene, along with four additional related genes, is located at the growth hormone locus on chromosome 17, sharing a high degree of sequence identity.
Alternative splicing results in five isoforms ranging from approximately 19 kDa to 24 kDa.
hGH is produced by somatotroph cells in the pituitary and acts through cytokine receptor family membrane receptors.
Its major role is to stimulate body growth by inducing IGF-1 secretion from the liver and other tissues.
It also promotes differentiation and proliferation of myoblasts, amino acid uptake, and protein synthesis in muscle and other tissues.
Mutations or deletions in the GH1 gene can lead to growth hormone deficiency and short stature.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.