Thermo Fisher Scientific CCL5 (RANTES) Monoclonal Antibody (53405.111)

Applications

Tested Dilution

Publications

Immunocytochemistry (ICC/IF)

8-25 µg/mL

-

ELISA (ELISA)

-

View 1 publication 1 publication

Neutralization (Neu)

Assay-dependent

-

Inhibition Assays (IA)

Assay-dependent

-

Product Specifications

Species Reactivity

Mouse

Published species

Human

Host/Isotype

Rat / IgG2a

Class

Monoclonal

Type

Antibody

Clone

53405.111

Immunogen

Recombinant, full length mouse protein, expressed in E. coli. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:CCL5 (RANTES),uniProtId:P30882-1,ncbiNodeId:10090,antigenRange:1-91,antigenLength:91,antigenImageFileName:MA1-24665_CCL5_RANTES_P30882-1_Rat.svg,antigenImageFileNamePDP:MA1-24665_CCL5_RANTES_P30882-1_Rat_PDP.jpeg,sortOrder:2}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Purification

Protein G

Storage buffer

PBS, pH 7.4, with 5% trehalose

Contains

no preservative

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_795296

Product Specific Information

Recommended positive controls: mouse splenocytes.

MA1-24665 has been successfully used in ICC/IF and inhibition procedures.

Target Information

CCL5 (RANTES) is a chemokine gene located on the q-arm of chromosome 17. Chemokines are a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. CCL5, a member of the CC subfamily, functions as a chemoattractant for blood monocytes, memory T helper cells, and eosinophils. It causes the release of histamine from basophils and activates eosinophils. This cytokine is one of the major HIV-suppressive factors produced by CD8+ cells. It functions as one of the natural ligands for the chemokine receptor chemokine (C-C motif) receptor 5 (CCR5), and it suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor. Alternative splicing results in multiple transcript variants that encode different isoforms. Diseases associated with CCL5 include Human Immunodeficiency Virus Type 1 and Periapical Granuloma.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.