Thermo Fisher Scientific CXCR1 Monoclonal Antibody (42705.111)

Applications

Tested Dilution

Publications

Immunohistochemistry (Frozen) (IHC (F))

25 µg/mL

-

Flow Cytometry (Flow)

10 µg/mL

-

Neutralization (Neu)

Assay-dependent

-

Inhibition Assays (IA)

0.1-0.3 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG2a

Class

Monoclonal

Type

Antibody

Clone

42705.111

Immunogen

Human CXCR1 transfected NSO mouse myeloma cells.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Purification

purified

Storage buffer

PBS with 5% trehalose

Contains

no preservative

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_779600

Product Specific Information

Recommended positive controls: human spleen.

Human CXCR1 reacts with CXCR1 transfected cells and not with the parent cell line by flow cytometry. Thw antibody shows no cross-reactivity with human CXCR2.

Endotoxin level is less than 10 ng per mg antibody as determined by the LAL method.

Target Information

CXCR1 is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. Knockout studies in mice suggested that this protein inhibits embryonic oligodendrocyte precursor migration in developing spinal cord. This gene, IL8RB, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.