Thermo Fisher Scientific CXCR1 Monoclonal Antibody (42705.111)
인간 CXCR1 단백질을 인식하는 마우스 단클론 항체. IHC, Flow Cytometry, Neutralization 등 다양한 어플리케이션에 사용 가능. 비결합형 액상 형태로 제공되며, 낮은 엔도톡신 수준 보유. 연구용으로만 사용 가능.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Frozen) (IHC (F)) | 25 µg/mL |
| Flow Cytometry (Flow) | 10 µg/mL |
| Neutralization (Neu) | Assay-dependent |
| Inhibition Assays (IA) | 0.1–0.3 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 42705.111 |
| Immunogen | Human CXCR1 transfected NSO mouse myeloma cells |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Purified |
| Storage Buffer | PBS with 5% trehalose |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_779600 |
Product Specific Information
- Recommended positive control: human spleen
- Human CXCR1 reacts with CXCR1 transfected cells and not with the parent cell line by flow cytometry.
- The antibody shows no cross-reactivity with human CXCR2.
- Endotoxin level is less than 10 ng per mg antibody as determined by the LAL method.
Target Information
CXCR1 is a member of the G-protein-coupled receptor family and serves as a receptor for interleukin 8 (IL8). It binds IL8 with high affinity and transduces signals via a G-protein–activated second messenger system. Knockout studies in mice suggest that CXCR1 inhibits embryonic oligodendrocyte precursor migration in the developing spinal cord. The IL8RB gene, encoding another high-affinity IL8 receptor, and IL8RBP, a pseudogene of IL8RB, form a gene cluster mapped to chromosome 2q33–q36.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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