Thermo Fisher Scientific Phospho-Huntington (Ser434) Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• Store vial at -20°C prior to opening.
• Aliquot contents and freeze at -20°C or below for extended storage.
• Avoid cycles of freezing and thawing.
• Centrifuge product if not completely clear after standing at room temperature.
• Stable for several weeks at 4°C as an undiluted liquid.
• Dilute only prior to immediate use.

Anti-Huntingtin pS434 antibody is directed against the phosphorylated form of the S434 residue.
BLAST analysis suggests cross-reactivity with human and mouse based on 100% sequence homology.
Cross-reactivity with Huntington pS434 from other sources has not been determined.

Target Information

Huntingtin is the disease gene linked to Huntington’s disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons.
This condition is caused by an expanded, unstable trinucleotide repeat in the huntingtin gene, translating as a polyglutamine repeat in the protein product.
HD is a mid-life onset autosomal dominant neurodegenerative disease characterized by psychiatric disorders, dementia, and involuntary movements (chorea), leading to death within 10–20 years.

The huntingtin locus spans 180 kb and consists of 67 exons.
The gene is widely expressed and required for normal development, producing two alternatively polyadenylated forms with different abundance in fetal and adult tissues.
The larger transcript (~13.7 kb) is expressed mainly in brain, while the smaller (~10.3 kb) is more broadly expressed.
The genetic defect may not eliminate transcription but can alter mRNA properties or protein function.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.