Thermo Fisher Scientific FOXP2 Recombinant Human Monoclonal Antibody (RAB-S249)
FOXP2 단백질을 인식하는 인간 유래 재조합 단클론 항체로, Flow Cytometry, ELISA, IP 등 다양한 면역분석에 사용 가능. 비결합형 액상 형태로 제공되며, 1 mg/mL 농도. FOXP2의 발현 및 기능 연구에 적합.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Flow Cytometry (Flow) | Assay-dependent | - |
| ELISA (ELISA) | Assay-dependent | - |
| Immunoprecipitation (IP) | Assay-dependent | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Human / F(ab), kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | RAB-S249 |
| Immunogen | This antibody was obtained by recombinant antibody (rAb) phage display recognizing FOXP2 protein under non-denaturing conditions. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Metal-chelate chromatography |
| Storage buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
Product Specific Information
This antibody recognizes FOXP2 (Forkhead box protein P2) and binds to a folded domain (amino acids 306–411).
FOXP2 is a transcriptional repressor involved in the specification and differentiation of lung epithelium.
Target Information
FOXP2 belongs to the forkhead/winged-helix (FOX) family of transcription factors.
It is expressed in fetal and adult brain, lung, and gut. The protein contains a FOX DNA-binding domain and a polyglutamine tract.
FOXP2 regulates expression of 300–400 gene promoters and is essential for proper development of speech and language regions in the brain.
Mutations in FOXP2 cause speech-language disorder 1 (SPCH1), also known as autosomal dominant speech and language disorder with orofacial dyspraxia.
Multiple alternative transcripts encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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