Thermo Fisher Scientific MAP2K1 Monoclonal Antibody (OTI4H1), TrueMAB
MAP2K1(MEK1) 단백질을 인식하는 Mouse monoclonal antibody(OTI4H1)로, WB, IHC(P), ICC/IF에 사용 가능. Human, Mouse, Rat, Dog 반응성. Lyophilized 형태, PBS buffer(8% trehalose) 포함, -20°C 보관. 연구용 전용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:200–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
| Immunocytochemistry (ICC/IF) | 1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Dog, Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI4H1 |
| Immunogen | Full length human recombinant protein of human MAP2K1 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, it is recommended to perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
MAP2K1 (MEK1) kinase is a dual-specificity protein kinase functioning in mitogen-activated protein kinase (MAPK) cascades, regulating cell growth and differentiation.
It is activated by various growth factors, cytokines, membrane depolarization, and calcium influx.
Phosphorylation of serine residues 218 and 222 by Raf1 activates Mek1.
It is involved in stress response signaling, apoptosis, and cytokine-induced proliferation.
Mutations in MAP2K1 can cause cardiofaciocutaneous syndrome.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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