Thermo Fisher Scientific RAB21 Monoclonal Antibody (OTI6B1), TrueMAB
RAB21 단백질을 표적으로 하는 Mouse Monoclonal Antibody로 Western Blot 및 IHC(Paraffin) 실험에 적합. HEK293T 세포에서 생산된 전체 길이 인간 RAB21 단백질을 면역원으로 사용. 고순도 Affinity chromatography 정제, Lyophilized 형태로 제공. 연구용으로만 사용 가능.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI6B1 |
| Immunogen | Full length human recombinant protein of human RAB21 produced in HEK293T cells |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL of distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
RAB21 is a member of the small GTP-binding protein subfamily within the Ras superfamily, playing a crucial role in intracellular vesicular trafficking.
In non-polarized Caco-2 cells, RAB21 localizes to the endoplasmic reticulum, while in polarized cells, it associates with apical vesicles.
RAB21 interacts with integrin subunits and facilitates receptor entry via RAB5/RAB21 endosomes. The GTPase-activating protein p120RasGAP regulates cell motility by modulating integrin recycling through competitive binding with RAB21.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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