ELK Biotechnology MKP-3 rabbit pAb
MKP-3(DUSP6) 단백질 인산화효소에 특이적인 토끼 폴리클로날 항체로, WB, IHC, IF, ELISA에 사용 가능. 세포 내 ERK2 불활성화 연구에 적합하며 사람, 생쥐, 랫트에 반응. 고순도 IgG, 1 mg/ml 농도, -20°C 보관.
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제품명
MKP-3 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | DUSP6; MKP3; PYST1; Dual specificity protein phosphatase 6; Dual specificity protein phosphatase PYST1; Mitogen-activated protein kinase phosphatase 3; MAP kinase phosphatase 3; MKP-3 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500–1/2000 Immunohistochemistry: 1/100–1/300 Immunofluorescence: 1/200–1/1000 ELISA: 1/20000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human DUSP6 (AA range: 61–110) |
| Host | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 42 kD |
| Gene ID (Human) | 1848 |
| Human Swiss-Prot No. | Q16828 |
| Cellular Localization | Cytoplasm |
| Species Reactivity | Human; Mouse; Rat |
Background
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation.
Different members of this family show distinct substrate specificities for various MAP kinases, tissue distribution, subcellular localization, and inducibility by extracellular stimuli. This gene product inactivates ERK2, is expressed in various tissues (highest in heart and pancreas), and is localized in the cytoplasm.
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