Thermo Fisher Scientific JPH3 Polyclonal Antibody
JPH3 단백질을 인식하는 Rabbit Polyclonal 항체로, WB 및 IHC에 적합합니다. Human, Mouse, Rat 시료에 반응하며, 항원 친화 크로마토그래피로 정제되었습니다. PBS 버퍼에 0.02% sodium azide가 포함되어 있으며, 냉장 또는 냉동 보관이 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1 µg/mL |
| Immunohistochemistry (IHC) | 2.5 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | An 18 amino acid peptide near the center of human JPH3 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.78 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long-term storage, store at -20°C. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11157411 |
Product Specific Information
- Suggested positive control: Daudi cell lysate
- PA5-20644 can be used with blocking peptide PEP-0764
Target Information
Junctional complexes between the plasma membrane (PM) and endoplasmic/sarcoplasmic reticulum (ER/SR) are characteristic of excitable cells, mediating cross talk between cell surface and intracellular ion channels.
Junctophilins (JPs) are key components of these complexes, composed of a carboxy-terminal hydrophobic segment spanning the ER/SR membrane and a cytoplasmic domain with affinity for the PM.
Four JP subtypes have been identified:
- JPH1: Expressed in skeletal muscle
- JPH2: Found in all muscle cell types
- JPH3, JPH4: Predominantly expressed in the brain
In the CNS, JPH3 and JPH4 contribute to subsurface cistern formation in neurons. Mice lacking both subtypes show impaired learning, memory, and abnormal nervous functions.
A repeat expansion in JPH3 is associated with Huntington disease-like 2. At least two isoforms of JPH3 are known.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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