Thermo Fisher Scientific HDAC4 Monoclonal Antibody (OTI1E1), TrueMAB

Applications and Tested Dilution

• Western Blot (WB): 1:2,000

Product Specifications

Product Specific Information

For reconstitution, add 100 µL of distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, an additional desalting step is recommended (Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

Histone deacetylase 4 (HDAC4) is responsible for the deacetylation of lysine residues on the N-terminal part of core histones (H2A, H2B, H3, and H4).
This deacetylation acts as a tag for epigenetic repression and plays a key role in transcriptional regulation, cell cycle progression, and developmental processes.
HDAC4 functions within large multiprotein complexes and is involved in muscle maturation through interactions with myocyte enhancer factors (MEF2A, MEF2C, MEF2D).
It also contributes to MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer.
Mutations in the HDAC4 gene are associated with Brachydactyly-mental retardation syndrome (BDMR).

For Research Use Only. Not for use in diagnostic procedures or resale without authorization.