Thermo Fisher Scientific COL11A1 Recombinant Rabbit Monoclonal Antibody (23GB5100)

Applications

• Western Blot (WB): 1:1,000–1:5,000

Product Specifications

Target Information

Collagen Type XI is an 1806 amino acid protein belonging to the fibrillar collagen family. It plays an important role in fibrillogenesis by controlling the lateral growth of collagen II fibrils. This protein forms trimers composed of three different chains: α1(XI), α2(XI), and α3(XI), where α3(XI) is a post-translational modification of α1(II). α1(V) can also be found instead of α3(XI).
Collagen Type XI has three named isoforms (A, B, C), and additional isoforms may exist due to alternative usage of exon IIA or IIB. Transcripts containing exon IIA or IIB are present in cartilage, but exon IIB is preferentially utilized in tendon.
It contains a single collagen-binding TSP N-terminal (TSPN) domain and is expressed in cartilage, placenta, and some tumor or virally transformed cell lines. Isoform expression can be tissue specific.
Defects in the COL11A gene cause Stickler syndrome type 2 (STL2), or beaded vitreous type, characterized by irregularly thickened fiber bundles throughout the vitreous cavity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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